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AI-Designed Nanobodies Gain Protein A Purification Superpowers
Unpacking a Cell Discovery study that couples diffusion-based generative design with structure-aware ranking to reprogram single-domain antibodies for Protein A capture without sacrificing antigen specificity.
Autophagy-ER Stress Crosstalk Unites T2DM and MAFLD Risk
Breaking down a Scientific Reports study that uses integrated bulk and single-cell transcriptomics to uncover RELB, S100A9, SOCS1, and CDKN1A as shared drivers between type 2 diabetes and fatty liver disease.
Machine Learning Models Decode APOBEC Signatures in Kidney Cancer
Diving into a Scientific Reports study that leverages APOBEC cytidine deaminase activity and machine learning to stratify clear cell renal carcinoma prognosis.
m6A-Regulated Cell Death Signals Guide Leukemia Prognosis
Exploring a Scientific Reports study that links m6A-driven programmed cell death genes to prognosis in acute lymphoblastic leukemia and what it means for precision hematology.